To promote cutting-edge technologies to interrogate epigenetic and proteomic changes at the single cell and single locus resolution.
The enabling technology will facilitate the elucidation of fundamental mechanisms of cell heterogeneity that offers translational potential for interrogating rare cell populations.
In our Biosciences Initiative Exploratory Funding (BIEF) proposal, we propose to develop, import, and distribute to the University of Michigan research community reagents and technologies that will enable single-cell and locus-specific chromatin proteomics. This capability will permit the elucidation of fundamental mechanisms underlying cell- and locus-specific transcriptional heterogeneities both during normal development and in disease.
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